While working at Cloud Nine, I was the frontend developer in a small team that made a new website for First Hotels. Episerver was the content management system, the challenge was to create a better booking experience and support all of the 50 or so hotels.
Accessible XHTML and custom javascripts that should play along nicely with the Episerver system, together with a somewhat complicated page layout, made this a bit tricky. But it turned out pretty nice.